| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-TAS2R4 (Cytoplasmic Domain) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Tas2r4 |
| Gene ID: | 57253 |
| Uniprot ID: | TA2R4_MOUSE |
| Immunogen Region: | Cytoplasmic Domain |
| Specificity: | Specific for TAS2R4. |
| Immunogen: | A synthetic peptide from a cytoplasmic domain of mouse TAS2R4 conjugated to blue carrier protein was used as the antigen. |
| Function | Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. |
| Protein Name | Taste Receptor Type 2 Member 4T2r4Taste Receptor Type 2 Member 8T2r8 |
| Database Links | Reactome: R-MMU-418594Reactome: -MMU-420499Reactome: -MMU-9717207 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell ProjectionCilium MembraneIn Airway Epithelial CellsLocalizes To Motile Cilia |
| Alternative Antibody Names | Anti-Taste Receptor Type 2 Member 4 antibodyAnti-T2r4 antibodyAnti-Taste Receptor Type 2 Member 8 antibodyAnti-T2r8 antibodyAnti-Tas2r4 antibodyAnti-Tas2r108 antibodyAnti-Tas2r8 antibody |
Information sourced from Uniprot.org