| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TADA2A |
| Gene ID: | 6871 |
| Uniprot ID: | TAD2A_HUMAN |
| Immunogen Region: | 1-443 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-443 of human TADA2A (NP_001159577.2). |
| Immunogen Sequence: | MDRLGSFSNDPSDKPPCRGC SSYLMEPYIKCAECGPPPFF LCLQCFTRGFEYKKHQSDHT YEIMTSDFPVLDPSWTAQEE MALLEAVMDCGFGNWQDVAN QMCTKTKEECEKHYMKHFIN NPLFASTLLNLKQAEEAKTA DTAIPFHSTDDPPRPTFDSL LSRDMAGYMPARADFIEEFD NYAEWDLRDIDFVEDDSDIL HALKMAVVDIYHSRLKERQR RKKIIRDHGLINLRKFQLM |
| Tissue Specificity | Expressed in all tissues, but most abundantly in testis. |
| Function | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. |
| Protein Name | Transcriptional Adapter 2-AlphaTranscriptional Adapter 2-LikeAda2-Like Protein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Transcriptional Adapter 2-Alpha antibodyAnti-Transcriptional Adapter 2-Like antibodyAnti-Ada2-Like Protein antibodyAnti-TADA2A antibodyAnti-TADA2L antibodyAnti-KL04P antibody |
Information sourced from Uniprot.org