| Post Translational Modifications | Degraded in a lysosome-dependent manner following interaction with TRIM38. SUMOylated by TRIM60.leading to inhibition of MAPK/NF-kappaB activation and the innate immune response. Ubiquitinated.following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. Ubiquitinated at Lys-611 by TRIM45 leading to proteasomal degradation. Phosphorylated. (Microbial infection) Methylated at Cys-673 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation. |
| Function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development. |
| Protein Name | Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 2Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2Tak1-Binding Protein 2Tab-2Tgf-Beta-Activated Kinase 1-Binding Protein 2 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-168638Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-5357956Reactome: R-HSA-5607764Reactome: R-HSA-9014325Reactome: R-HSA-9020702Reactome: R-HSA-937042Reactome: R-HSA-937072Reactome: R-HSA-9645460Reactome: R-HSA-9705671Reactome: R-HSA-975163 |
| Cellular Localisation | MembranePeripheral Membrane ProteinEndosome MembraneLysosome MembraneCytoplasmCytosolFollowing Il1 StimulationTranslocation Occurs From The Membrane To CytosolInteraction With Trim38 Promotes Translocation From Cytosol To Endosome And Lysosome |
| Alternative Antibody Names | Anti-Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 2 antibodyAnti-Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2 antibodyAnti-Tak1-Binding Protein 2 antibodyAnti-Tab-2 antibodyAnti-Tgf-Beta-Activated Kinase 1-Binding Protein 2 antibodyAnti-TAB2 antibodyAnti-KIAA0733 antibodyAnti-MAP3K7IP2 antibody |
Information sourced from Uniprot.org
