Anti-T-bet antibody [IHC670] (STJA0042268)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
General Information
| Short Description | Rabbit monoclonal anti-T-bet for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC670 |
| Conjugation | Unconjugated |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Specificity | Tested and validated on hairy cell leukemia, tonsil tissue. |
Additional Info
| Background | T-bet is a transcription factor present in CD4+ T-cells. Anti-T-bet stains mature T-lymphocytes, but is scarcely present in T helper cells. Nuclear staining is observed in the interfollicular T-cell zone of reactive lymphoid tissue (tonsil, lymph node, and spleen) and absent in germinal centers, mantle zones, and marginal zones. Anti-T-bet also stains certain B-cell lymphoproliferative disorders, such as precursor B-cell lymphoblastic leukemia and lymphoblastic lymphoma, and B-cell neoplasms from mature B-cells, marginal zone lymphoma, and hairy cell leukemia. Anti-T-bet is useful for identifying B cell and T-cell lymphoproliferative disorders, as it does not stain B-cell neoplasms from the pre-germinal center or germinal center B-cells, such as mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. |
Information sourced from Uniprot.org