| Short Description : | Rabbit monoclonal anti-T-bet for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-p |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | IHC670 |
| Conjugation: | Unconjugated |
| Formulation: | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction: | Store at 2-8°C for up to 1 year. Do not freeze. |
| Specificity: | Tested and validated on hairy cell leukemia, tonsil tissue. |
| Background | T-bet is a transcription factor present in CD4+ T-cells. Anti-T-bet stains mature T-lymphocytes, but is scarcely present in T helper cells. Nuclear staining is observed in the interfollicular T-cell zone of reactive lymphoid tissue (tonsil, lymph node, and spleen) and absent in germinal centers, mantle zones, and marginal zones. Anti-T-bet also stains certain B-cell lymphoproliferative disorders, such as precursor B-cell lymphoblastic leukemia and lymphoblastic lymphoma, and B-cell neoplasms from mature B-cells, marginal zone lymphoma, and hairy cell leukemia. Anti-T-bet is useful for identifying B cell and T-cell lymphoproliferative disorders, as it does not stain B-cell neoplasms from the pre-germinal center or germinal center B-cells, such as mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. |
Information sourced from Uniprot.org
![Anti-T-bet antibody [MRQ-46] (STJ16100444)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/149161/346783/STJ16100444_1__12290.1681998885.jpg?c=1 "Anti-T-bet antibody [MRQ-46] (STJ16100444)")