| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Synaptotagmin-10 (380-460 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SYT10 |
| Gene ID: | 341359 |
| Uniprot ID: | SYT10_HUMAN |
| Immunogen Region: | 380-460 aa |
| Specificity: | Synaptotagmin X Polyclonal Antibody detects endogenous levels of Synaptotagmin X protein. |
| Immunogen: | Synthesized peptide derived from Synaptotagmin X at the amino acid range 380-460 |
| Function | Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis. Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes.both actions contribute to triggering exocytosis. |
| Protein Name | Synaptotagmin-10Synaptotagmin XSytx |
| Database Links | Reactome: R-HSA-6794361Reactome: R-HSA-9768919 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneSingle-Pass Membrane ProteinLocalizes To Neuronal Vesicles Containing Igf1 That Are Not Enriched At SynapsesDoes Not Colocalize With Synaptic Vesicles Or With The Golgi Apparatus |
| Alternative Antibody Names | Anti-Synaptotagmin-10 antibodyAnti-Synaptotagmin X antibodyAnti-Sytx antibodyAnti-SYT10 antibody |
Information sourced from Uniprot.org
