Anti-Syntenin 1 antibody [ZN69] (STJA0033331)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenFull length human recombinant protein of human SDCBP (NP_005616) produced in HEK293T cell.
General Information
| Short Description | Mouse monoclonal anti-Syntenin 1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZN69 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.0 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SDCBP |
| Gene ID | 6386 |
| Uniprot ID | SDCB1_HUMAN |
| Immunogen | Full length human recombinant protein of human SDCBP (NP_005616) produced in HEK293T cell. |
Additional Info
| Tissue Specificity | Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. |
| Protein Name | Syntenin-1Melanoma Differentiation-Associated Protein 9Mda-9Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18Tacip18Scaffold Protein Pbp1Syndecan-Binding Protein 1 |
| Database Links | Reactome: R-HSA-3928664Reactome: R-HSA-447043Reactome: R-HSA-5213460Reactome: R-HSA-5675482Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell JunctionFocal AdhesionAdherens JunctionCell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneNucleusMelanosomeCytoplasmCytosolCytoskeletonSecretedExtracellular ExosomeMembrane RaftMainly Membrane-AssociatedLocalized To Adherens JunctionsFocal Adhesions And Endoplasmic ReticulumColocalized With Actin Stress FibersAlso Found In The NucleusIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvAssociated To The Plasma Membrane In The Presence Of Fzd7 And Phosphatidylinositol 45-Bisphosphate (Pip2) |
| Alternative Antibody Names | Anti-Syntenin-1 antibodyAnti-Melanoma Differentiation-Associated Protein 9 antibodyAnti-Mda-9 antibodyAnti-Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18 antibodyAnti-Tacip18 antibodyAnti-Scaffold Protein Pbp1 antibodyAnti-Syndecan-Binding Protein 1 antibodyAnti-SDCBP antibodyAnti-MDA9 antibodyAnti-SYCL antibody |
Information sourced from Uniprot.org