| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SYNGAP1 (60-72) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 150kDa band observed in Mouse Brain lysates (calculated MW of 148kDa according to Human NP_006763.2 and Mouse XP_990642.3). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SYNGAP1 |
| Gene ID: | 8831 |
| Uniprot ID: | SYGP1_HUMAN |
| Immunogen Region: | 60-72 |
| Accession Number: | NP_006763.2 |
| Immunogen Sequence: | DEDEIHPLLIRDR |
| Function | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. |
| Protein Name | Ras/Rap Gtpase-Activating Protein SyngapNeuronal RasgapSynaptic Ras Gtpase-Activating Protein 1Synaptic Ras-Gap 1 |
| Database Links | Reactome: R-HSA-5658442 |
| Alternative Antibody Names | Anti-Ras/Rap Gtpase-Activating Protein Syngap antibodyAnti-Neuronal Rasgap antibodyAnti-Synaptic Ras Gtpase-Activating Protein 1 antibodyAnti-Synaptic Ras-Gap 1 antibodyAnti-SYNGAP1 antibodyAnti-KIAA1938 antibody |
Information sourced from Uniprot.org