Host: | Goat |
Applications: | Pep-ELISA/WB |
Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-SYNGAP1 (60-72) is suitable for use in ELISA and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | WB-1-3µg/ml ELISA-antibody detection limit dilution 1:32000. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | SYNGAP1 |
Gene ID: | 8831 |
Uniprot ID: | SYGP1_HUMAN |
Immunogen Region: | 60-72 |
Accession Number: | NP_006763.2 |
Immunogen Sequence: | DEDEIHPLLIRDR |
Function | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. |
Protein Name | Ras/Rap Gtpase-Activating Protein Syngap Neuronal Rasgap Synaptic Ras Gtpase-Activating Protein 1 Synaptic Ras-Gap 1 |
Database Links | Reactome: R-HSA-5658442 |
Alternative Antibody Names | Anti-Ras/Rap Gtpase-Activating Protein Syngap antibody Anti-Neuronal Rasgap antibody Anti-Synaptic Ras Gtpase-Activating Protein 1 antibody Anti-Synaptic Ras-Gap 1 antibody Anti-SYNGAP1 antibody Anti-KIAA1938 antibody |
Information sourced from Uniprot.org