| Host: | Rabbit |
| Applications: | IHC-P/WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Synapsin 2 (420-470) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC-P, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SYN2 |
| Gene ID: | 6854 |
| Uniprot ID: | SYN2_HUMAN |
| Immunogen Region: | 420-470 |
| Specificity: | Specific for Synapsin-2. |
| Immunogen: | A synthetic peptide from aa region 420-470 of human Synapsin-2 conjugated to blue carrier protein was used as the antigen. The peptide shares 90% identity with mouse and rat sequences. |
| Post Translational Modifications | Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons. |
| Function | Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons. |
| Protein Name | Synapsin-2Synapsin Ii |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-212676 |
| Cellular Localisation | Synapse |
| Alternative Antibody Names | Anti-Synapsin-2 antibodyAnti-Synapsin Ii antibodyAnti-SYN2 antibody |
Information sourced from Uniprot.org