• Western blot analysis of K562, 22RV-1, H460 cells using SCP-3 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-SYCP3 antibody (Internal) (STJ96482)

SKU:
STJ96482

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Synaptonemal complex protein 3 (Internal) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SYCP3
Gene ID: 50511
Uniprot ID: SYCP3_HUMAN
Immunogen Region: Internal
Specificity: SCP-3 Polyclonal Antibody detects endogenous levels of SCP-3 protein.
Immunogen: Synthesized peptide derived from the Internal region of human SCP-3.
Post Translational Modifications Phosphorylated.
Function Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
Protein Name Synaptonemal Complex Protein 3
Scp-3
Database Links Reactome: R-HSA-1221632
Cellular Localisation Nucleus
Chromosome
Centromere
It Is Present In Early Unpaired Cores
In The Lateral Domains Of The Synaptonemal Complex And In The Chromosome Cores When They Separate At Diplotene
It Is Found Axial To The Metaphase I Chromosomes And In Association With Pairs Of Sister Centromeres
The Centromere-Associated Protein Becomes Dissociated From The Centromeres At Anaphase Ii And Is Not Found In Mitotic Metaphase Centromeres
Alternative Antibody Names Anti-Synaptonemal Complex Protein 3 antibody
Anti-Scp-3 antibody
Anti-SYCP3 antibody
Anti-SCP3 antibody

Information sourced from Uniprot.org

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