| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM13612 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB, 1:1000-1:2000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SUZ12 |
| Gene ID: | 23512 |
| Uniprot ID: | SUZ12_HUMAN |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Immunogen Sequence: | Human |
| Post Translational Modifications | Sumoylated, probably by PIAS2. |
| Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
| Protein Name | Polycomb Protein Suz12Chromatin Precipitated E2f Target 9 ProteinChet 9 ProteinJoined To Jazf1 ProteinSuppressor Of Zeste 12 Protein Homolog |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214841Reactome: R-HSA-4551638Reactome: R-HSA-5617472Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Polycomb Protein Suz12 antibodyAnti-Chromatin Precipitated E2f Target 9 Protein antibodyAnti-Chet 9 Protein antibodyAnti-Joined To Jazf1 Protein antibodyAnti-Suppressor Of Zeste 12 Protein Homolog antibodyAnti-SUZ12 antibodyAnti-CHET9 antibodyAnti-JJAZ1 antibodyAnti-KIAA0160 antibody |
Information sourced from Uniprot.org
