| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SUMO3 (1-92) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SUMO3 |
| Gene ID: |
6612 |
| Uniprot ID: |
SUMO3_HUMAN |
| Immunogen Region: |
1-92 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human SUMO3 (NP_008867.2). |
| Immunogen Sequence: |
MSEEKPKEGVKTENDHINLK VAGQDGSVVQFKIKRHTPLS KLMKAYCERQGLSMRQIRFR FDGQPINETDTPAQLEMEDE DTIDVFQQQTGG |
| Tissue Specificity | Expressed predominantly in liver. |
| Post Translational Modifications | Polymeric chains can be formed through Lys-11 cross-linking. Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function. |
| Function | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX. |
| Protein Name | Small Ubiquitin-Related Modifier 3Sumo-3Smt3 Homolog 1Sumo-2Ubiquitin-Like Protein Smt3aSmt3a |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678Reactome: R-HSA-3065679Reactome: R-HSA-3108214Reactome: R-HSA-3232118Reactome: R-HSA-3899300Reactome: R-HSA-4090294Reactome: R-HSA-4551638Reactome: R-HSA-4615885Reactome: R-HSA-4755510Reactome: R-HSA-5696395 |
| Cellular Localisation | CytoplasmNucleusPml Body |
| Alternative Antibody Names | Anti-Small Ubiquitin-Related Modifier 3 antibodyAnti-Sumo-3 antibodyAnti-Smt3 Homolog 1 antibodyAnti-Sumo-2 antibodyAnti-Ubiquitin-Like Protein Smt3a antibodyAnti-Smt3a antibodyAnti-SUMO3 antibodyAnti-SMT3A antibodyAnti-SMT3H1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
