| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SULT2B1 (1-365) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SULT2B1 |
| Gene ID: |
6820 |
| Uniprot ID: |
ST2B1_HUMAN |
| Immunogen Region: |
1-365 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human SULT2B1 (NP_814444.1). |
| Immunogen Sequence: |
MDGPAEPQIPGLWDTYEDDI SEISQKLPGEYFRYKGVPFP VGLYSLESISLAENTQDVRD DDIFIITYPKSGTTWMIEII CLILKEGDPSWIRSVPIWER APWCETIVGAFSLPDQYSPR LMSSHLPIQIFTKAFFSSKA KVIYMGRNPRDVVVSLYHYS KIAGQLKDPGTPDQFLRDFL KGEVQFGSWFDHIKGWLRMK GKDNFLFITYEELQQDLQGS VERICGFLGRPLGKEALGS |
| Tissue Specificity | Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. |
| Post Translational Modifications | Phosphorylated. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation. Isoform 2: Sulfonates pregnenolone but not cholesterol. |
| Protein Name | Sulfotransferase 2b1Alcohol SulfotransferaseHydroxysteroid Sulfotransferase 2Sulfotransferase Family 2b Member 1Sulfotransferase Family Cytosolic 2b Member 1St2b1 |
| Database Links | Reactome: R-HSA-156584 |
| Cellular Localisation | CytoplasmCytosolMicrosomeNucleusPhosphorylation Of Ser-348 Is Required For Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Sulfotransferase 2b1 antibodyAnti-Alcohol Sulfotransferase antibodyAnti-Hydroxysteroid Sulfotransferase 2 antibodyAnti-Sulfotransferase Family 2b Member 1 antibodyAnti-Sulfotransferase Family Cytosolic 2b Member 1 antibodyAnti-St2b1 antibodyAnti-SULT2B1 antibodyAnti-HSST2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
