Anti-STYX antibody (1-223) (STJ117515)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal STYX (1-223) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STYX |
| Gene ID | 6815 |
| Uniprot ID | STYX_HUMAN |
| Immunogen Region | 1-223 |
| Immunogen Sequence | MEDVKLEFPSLPQCKEDAEE WTYPMRREMQEILPGLFLGP YSSAMKSKLPVLQKHGITHI ICIRQNIEANFIKPNFQQLF RYLVLDIADNPVENIIRFFP MTKEFIDGSLQMGGKVLVHG NAGISRSAAFVIAYIMETFG MKYRDAFAYVQERRFCINPN AGFVHQLQEYEAIYLAKLTI QMMSPLQIERSLSVHSGTTG SLKRTHEEEDDFGTMQVATA QNG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human STYX (NP_660294.1). |
Additional Info
| Function | Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis. |
| Protein Name | Serine/Threonine/Tyrosine-Interacting ProteinInactive Tyrosine-Protein Phosphatase StyxPhosphoserine/Threonine/Tyrosine Interaction Protein |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytosolPredominantly Localizes To The Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine/Tyrosine-Interacting Protein antibodyAnti-Inactive Tyrosine-Protein Phosphatase Styx antibodyAnti-Phosphoserine/Threonine/Tyrosine Interaction Protein antibodyAnti-STYX antibody |
Information sourced from Uniprot.org