| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Syntaxin-binding protein 5-like giant larvae protein homolog 4 (990-1040 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STXBP5L |
| Gene ID: |
9515 |
| Uniprot ID: |
STB5L_HUMAN |
| Immunogen Region: |
990-1040 aa |
| Specificity: |
This antibody detects endogenous levels of STB5L at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human STB5L at the amino acid range 990-1040 |
| Post Translational Modifications | Phosphorylated, leading to STXBP5L increased turnover and subsequent de-repression of insulin secretion. Phosphorylated on serine residues in response to glucose or phorbol esters. Ubiquitinated by the E3 ligase SYVN1, leading to STXBP5L proteasomal degradation. |
| Function | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth. |
| Protein Name | Syntaxin-Binding Protein 5-LikeLethal(2 Giant Larvae Protein Homolog 4Tomosyn-2 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinMembraneCytoplasmicAnd Associated With Vesicular Membranes And The Plasma Membrane |
| Alternative Antibody Names | Anti-Syntaxin-Binding Protein 5-Like antibodyAnti-Lethal(2 Giant Larvae Protein Homolog 4 antibodyAnti-Tomosyn-2 antibodyAnti-STXBP5L antibodyAnti-KIAA1006 antibodyAnti-LLGL4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
