| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STX17 |
| Gene ID: | 55014 |
| Uniprot ID: | STX17_HUMAN |
| Immunogen Region: | 1-130 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human STX17 (NP_060389.2). |
| Immunogen Sequence: | MSEDEEKVKLRRLEPAIQKF IKIVIPTDLERLRKHQINIE KYQRCRIWDKLHEEHINAGR TVQQLRSNIREIEKLCLKVR KDDLVLLKRMIDPVKEEASA ATAEFLQLHLESVEELKKQF NDEETLLQPP |
| Post Translational Modifications | Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2.regulates exit from the endoplasmic reticulum. (Microbial infection) Cleaved by the L.pneumophila serine protease Lpg1137, impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy. |
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi. |
| Protein Name | Syntaxin-17 |
| Database Links | Reactome: R-HSA-204005 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Smooth Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cytoplasmic Vesicle Autophagosome Membrane Copii-Coated Vesicle Membrane Cytoplasm Cytosol Mitochondrion Membrane Has A Hairpin-Like Insertion Into Membranes Localizes To The Completed Autophagosome Membrane Upon Cell Starvation |
| Alternative Antibody Names | Anti-Syntaxin-17 antibody Anti-STX17 antibody |
Information sourced from Uniprot.org