Anti-ST8SIA4 antibody (20-168) (STJ28837)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ST8SIA4 (20-168) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ST8SIA4 |
| Gene ID | 7903 |
| Uniprot ID | SIA8D_HUMAN |
| Immunogen Region | 20-168 |
| Immunogen Sequence | YKTKEIARTEEHQETQLIGD GELSLSRSLVNSSDKIIRKA GSSIFQHNVEGWKINSSLVL EIRKNILRFLDAERDVSVVK SSFKPGDVIHYVLDRRRTLN ISHDLHSLLPEVSPMKNRRF KTCAVVGNSGILLDSECGKE IDSHNFVIR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-168 of human ST8SIA4 (NP_778222.1). |
Additional Info
| Tissue Specificity | Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes. |
| Post Translational Modifications | Autopolysialylated. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG. It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid. |
| Protein Name | Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-SialyltransferaseAlpha-2 -8-Sialyltransferase 8dPolysialyltransferasePolysialyltransferase-1Sialyltransferase 8dSiat8-DSialyltransferase St8sia IvSt8siaiv |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-419037 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecreted |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-Sialyltransferase antibodyAnti-Alpha-2 -8-Sialyltransferase 8d antibodyAnti-Polysialyltransferase antibodyAnti-Polysialyltransferase-1 antibodyAnti-Sialyltransferase 8d antibodyAnti-Siat8-D antibodyAnti-Sialyltransferase St8sia Iv antibodyAnti-St8siaiv antibodyAnti-ST8SIA4 antibodyAnti-PST antibodyAnti-PST1 antibodyAnti-SIAT8D antibody |
Information sourced from Uniprot.org