| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ST8SIA4 |
| Gene ID: | 7903 |
| Uniprot ID: | SIA8D_HUMAN |
| Immunogen Region: | 20-168 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-168 of human ST8SIA4 (NP_778222.1). |
| Immunogen Sequence: | YKTKEIARTEEHQETQLIGD GELSLSRSLVNSSDKIIRKA GSSIFQHNVEGWKINSSLVL EIRKNILRFLDAERDVSVVK SSFKPGDVIHYVLDRRRTLN ISHDLHSLLPEVSPMKNRRF KTCAVVGNSGILLDSECGKE IDSHNFVIR |
| Tissue Specificity | Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes. |
| Post Translational Modifications | Autopolysialylated. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG. It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid. |
| Protein Name | Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-Sialyltransferase Alpha-2 -8-Sialyltransferase 8d Polysialyltransferase Polysialyltransferase-1 Sialyltransferase 8d Siat8-D Sialyltransferase St8sia Iv St8siaiv |
| Database Links | Reactome: R-HSA-4085001 Reactome: R-HSA-419037 |
| Cellular Localisation | Golgi Apparatus Membrane Single-Pass Type Ii Membrane Protein Secreted |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-Sialyltransferase antibody Anti-Alpha-2 -8-Sialyltransferase 8d antibody Anti-Polysialyltransferase antibody Anti-Polysialyltransferase-1 antibody Anti-Sialyltransferase 8d antibody Anti-Siat8-D antibody Anti-Sialyltransferase St8sia Iv antibody Anti-St8siaiv antibody Anti-ST8SIA4 antibody Anti-PST antibody Anti-PST1 antibody Anti-SIAT8D antibody |
Information sourced from Uniprot.org