| Tissue Specificity | Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes. |
| Post Translational Modifications | Autopolysialylated. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG. It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid. |
| Protein Name | Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-SialyltransferaseAlpha-2 -8-Sialyltransferase 8dPolysialyltransferasePolysialyltransferase-1Sialyltransferase 8dSiat8-DSialyltransferase St8sia IvSt8siaiv |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-419037 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecreted |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Poly-Alpha-2 -8-Sialyltransferase antibodyAnti-Alpha-2 -8-Sialyltransferase 8d antibodyAnti-Polysialyltransferase antibodyAnti-Polysialyltransferase-1 antibodyAnti-Sialyltransferase 8d antibodyAnti-Siat8-D antibodyAnti-Sialyltransferase St8sia Iv antibodyAnti-St8siaiv antibodyAnti-ST8SIA4 antibodyAnti-PST antibodyAnti-PST1 antibodyAnti-SIAT8D antibody |
Information sourced from Uniprot.org
