| Tissue Specificity | Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus. |
| Post Translational Modifications | Autopolysialylated. Autopolysialylation is not a prerequisite for the polysialylation acitity, but enhances the polysialylation acitity. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (Probable). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (Probable). However, does not exhibit sialic acid-polymerase activity. Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth. ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons. |
| Protein Name | Alpha-2 -8-Sialyltransferase 8bSialyltransferase 8bSiat8-BSialyltransferase St8sia IiSt8siaiiSialyltransferase XStx |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-419037Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecretedCell MembraneAlso Trafficks To The Cell Surface |
| Alternative Antibody Names | Anti-Alpha-2 -8-Sialyltransferase 8b antibodyAnti-Sialyltransferase 8b antibodyAnti-Siat8-B antibodyAnti-Sialyltransferase St8sia Ii antibodyAnti-St8siaii antibodyAnti-Sialyltransferase X antibodyAnti-Stx antibodyAnti-ST8SIA2 antibodyAnti-SIAT8B antibodyAnti-STX antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and GPLD1 Rabbit polyclonal antibody knockdown (KD) 293T cells, using [KD Validated] GPLD1 Rabbit polyclonal antibody (STJ11104539) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/177183/368686/STJ11104539_1__82427.1713134155.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and GPLD1 Rabbit polyclonal antibody knockdown (KD) 293T cells, using [KD Validated] GPLD1 Rabbit polyclonal antibody (STJ11104539) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
