Western blot analysis of extracts of mouse liver, using SSH2 antibody (STJ112029) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5min.

Anti-SSH2 antibody (53-202) (STJ112029)

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STJ112029
€140.63 - €655.63
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SSH2
Gene ID: 85464
Uniprot ID: SSH2_HUMAN
Immunogen Region: 53-202
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 53-202 of human SSH2 (NP_203747.2).
Immunogen Sequence: RGNGSSTPRISHRRNKHAGD LQQHLQAMFILLRPEDNIRL AVRLESTYQNRTRYMVVVST NGRQDTEESIVLGMDFSSND SSTCTMGLVLPLWSDTLIHL DGDGGFSVSTDNRVHIFKPV SVQAMWSALQSLHKACEVAR AHNYYPGSLF
Function Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Required for spermatogenesis. Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking.
Protein Name Protein Phosphatase Slingshot Homolog 2
Ssh-Like Protein 2
Ssh-2l
Hssh-2l
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Junction
Focal Adhesion
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Colocalizes With Filamentous Actin In The Cytoplasm And The Cell Periphery
Alternative Antibody Names Anti-Protein Phosphatase Slingshot Homolog 2 antibody
Anti-Ssh-Like Protein 2 antibody
Anti-Ssh-2l antibody
Anti-Hssh-2l antibody
Anti-SSH2 antibody
Anti-KIAA1725 antibody
Anti-SSH2L antibody

Information sourced from Uniprot.org

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