| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Serine/arginine-rich splicing factor 3 (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRSF3 |
| Gene ID: | 6428 |
| Uniprot ID: | SRSF3_HUMAN |
| Immunogen Region: | 111-160 aa |
| Specificity: | SRp20 Polyclonal Antibody detects endogenous levels of SRp20 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SFRS3 at the amino acid range 111-160 |
| Function | Splicing factor, which binds the consensus motif 5'-CACUAUCACUACC-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway).enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 3 Pre-Mrna-Splicing Factor Srp20 Splicing Factor - Arginine/Serine-Rich 3 |
| Database Links | Reactome: R-HSA-159236 Reactome: R-HSA-72163 Reactome: R-HSA-72187 Reactome: R-HSA-72203 Reactome: R-HSA-73856 |
| Cellular Localisation | Nucleus Nucleus Speckle Cytoplasm Recruited To Nuclear Speckles Following Interaction With Ythdc1 |
| Alternative Antibody Names | Anti-Serine/Arginine-Rich Splicing Factor 3 antibody Anti-Pre-Mrna-Splicing Factor Srp20 antibody Anti-Splicing Factor - Arginine/Serine-Rich 3 antibody Anti-SRSF3 antibody Anti-SFRS3 antibody Anti-SRP20 antibody |
Information sourced from Uniprot.org