| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4208RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRR |
| Gene ID: | 63826 |
| Uniprot ID: | SRR_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Serine racemase (NP_068766.1). |
| Immunogen Sequence: | MCAQYCISFADVEKAHINIR DSIHLTPVLTSSILNQLTGR NLFFKCELFQKTGSFKIRGA LNAVRSLVPDALERKPKAVV THSSGNHGQALTYAAKLEGI |
| Tissue Specificity | Expressed in the cerebellum, hippocampus, dorsolateral prefrontal cortex, and in motor neurons and glial cells of the lumbar spinal cord (at protein level). Increased in the dorsolateral prefrontal cortex of schizophrenic patients (at protein level). Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney, and liver. |
| Post Translational Modifications | S-nitrosylated, leading to decrease the enzyme activity. |
| Function | Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. |
| Protein Name | Serine Racemase D-Serine Ammonia-Lyase D-Serine Dehydratase L-Serine Ammonia-Lyase L-Serine Dehydratase |
| Database Links | Reactome: R-HSA-977347 |
| Alternative Antibody Names | Anti-Serine Racemase antibody Anti-D-Serine Ammonia-Lyase antibody Anti-D-Serine Dehydratase antibody Anti-L-Serine Ammonia-Lyase antibody Anti-L-Serine Dehydratase antibody Anti-SRR antibody |
Information sourced from Uniprot.org