| Tissue Specificity | Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus. |
| Function | Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. |
| Protein Name | Steroid Receptor Rna Activator 1Steroid Receptor Rna Activator ProteinSrap |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Steroid Receptor Rna Activator 1 antibodyAnti-Steroid Receptor Rna Activator Protein antibodyAnti-Srap antibodyAnti-SRA1 antibodyAnti-PP7684 antibody |
Information sourced from Uniprot.org
