| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Squalene monooxygenase is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SQLE |
| Gene ID: | 6713 |
| Uniprot ID: | ERG1_HUMAN |
| Specificity: | This antibody detects endogenous levels of SQLE at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human SQLE |
| Post Translational Modifications | Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation. |
| Function | Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. |
| Protein Name | Squalene Monooxygenase Squalene Epoxidase Se |
| Database Links | Reactome: R-HSA-191273 Reactome: R-HSA-2426168 |
| Cellular Localisation | Microsome Membrane Peripheral Membrane Protein Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Squalene Monooxygenase antibody Anti-Squalene Epoxidase antibody Anti-Se antibody Anti-SQLE antibody Anti-ERG1 antibody |
Information sourced from Uniprot.org
