| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SQLE |
| Gene ID: | 6713 |
| Uniprot ID: | ERG1_HUMAN |
| Immunogen Region: | 300-574 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human SQLE (NP_003120.2). |
| Immunogen Sequence: | VSVSSHFVGFLMKNAPQFKA NHAELILANPSPVLIYQISS SETRVLVDIRGEMPRNLREY MVEKIYPQIPDHLKEPFLEA TDNSHLRSMPASFLPPSSVK K |
| Tissue Specificity | Detected in liver (at protein level). |
| Post Translational Modifications | Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation. |
| Function | Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. |
| Protein Name | Squalene MonooxygenaseSqualene EpoxidaseSe |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2426168 |
| Cellular Localisation | Microsome MembranePeripheral Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Squalene Monooxygenase antibodyAnti-Squalene Epoxidase antibodyAnti-Se antibodyAnti-SQLE antibodyAnti-ERG1 antibody |
Information sourced from Uniprot.org