| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SPSB1 (1-273) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPSB1 |
| Gene ID: |
80176 |
| Uniprot ID: |
SPSB1_HUMAN |
| Immunogen Region: |
1-273 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human SPSB1 (Q96BD6). |
| Immunogen Sequence: |
MGQKVTGGIKTVDMRDPTYR PLKQELQGLDYCKPTRLDLL LDMPPVSYDVQLLHSWNNND RSLNVFVKEDDKLIFHRHPV AQSTDAIRGKVGYTRGLHVW QITWAMRQRGTHAVVGVATA DAPLHSVGYTTLVGNNHESW GWDLGRNRLYHDGKNQPSKT YPAFLEPDETFIVPDSFLVA LDMDDGTLSFIVDGQYMGVA FRGLKGKKLYPVVSAVWGHC EIRMRYLNGLDPEPLPLMD |
| Function | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. |
| Protein Name | Spry Domain-Containing Socs Box Protein 1Ssb-1 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytosolExhibits A Diffuse Cytosolic Localization |
| Alternative Antibody Names | Anti-Spry Domain-Containing Socs Box Protein 1 antibodyAnti-Ssb-1 antibodyAnti-SPSB1 antibodyAnti-SSB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
