Anti-SPRED1 antibody (120-320) (STJ117169)

Name: Anti-SPRED1 antibody (120-320) (STJ117169)
SKU: STJ117169
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ117169

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Short Description	Rabbit polyclonal SPRED1 (120-320) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SPRED1
Gene ID	161742
Uniprot ID	SPRE1_HUMAN
Immunogen Region	120-320
Immunogen Sequence	IEDISQGCPESKNEAEGADD LQANEEDSSSSLVKDHLFQQ ETVVTSEPYRSSNIRPSPFE DLNARRVYMQSQANQITFGQ PGLDIQSRSMEYVQRQISKE CGSLKSQNRVPLKSIRHVSF QDEDEIVRINPRDILIRRYA DYRHPDMWKNDLERDDADSS IQFSKPDSKKSDYLYSCGDE TKLSSPKDSVVFKTQPSSLK I
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 120-320 of human SPRED1 (NP_689807.1).

Tissue Specificity	Weakly expressed in embryonic cell line HEK293.
Post Translational Modifications	Palmitoylated by ZDHHC17/HIP14. Phosphorylated on tyrosine. Ubiquitinated.
Function	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Protein Name	Sprouty-Related - Evh1 Domain-Containing Protein 1 Spred-1 Hspred1
Database Links	Reactome: R-HSA-5658442 Reactome: R-HSA-5658623 Reactome: R-HSA-6802953
Cellular Localisation	Cell Membrane Peripheral Membrane Protein Membrane Caveola Nucleus Localized In Cholesterol-Rich Membrane Raft/Caveola Fractions
Alternative Antibody Names	Anti-Sprouty-Related - Evh1 Domain-Containing Protein 1 antibody Anti-Spred-1 antibody Anti-Hspred1 antibody Anti-SPRED1 antibody

Information sourced from Uniprot.org