| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPIRE2 |
| Gene ID: | 84501 |
| Uniprot ID: | SPIR2_HUMAN |
| Immunogen Region: | 1-190 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human SPIRE2 (NP_115827.1). |
| Immunogen Sequence: | MARAGSCGGAAAGAGRPEPW ELSLEEVLKAYEQPLNEEQA WAVCFQGCRGLRGSPGRRLR DTGDLLLRGDGSVGAREPEA AEPATMVVPLASSEAQTVQS LGFAIYRALDWGLDESEERE LSPQLERLIDLMANNDSEDS GCGAADEGYGGPEEEEEAEG VPRSVRTFAQAMRLCAARLT DPRGAQAHYQ |
| Function | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. |
| Protein Name | Protein Spire Homolog 2 Spir-2 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cytosol Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasmic Vesicle Membrane Detected At The Cleavage Furrow During Asymmetric Oocyte Division And Polar Body Extrusion |
| Alternative Antibody Names | Anti-Protein Spire Homolog 2 antibody Anti-Spir-2 antibody Anti-SPIRE2 antibody Anti-KIAA1832 antibody Anti-SPIR2 antibody |
Information sourced from Uniprot.org