| Short Description : | Rabbit polyclonal SPDYA (1-313) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPDYA |
| Gene ID: | 245711 |
| Uniprot ID: | SPDYA_HUMAN |
| Immunogen Region: | 1-313 |
| Immunogen Sequence: | MRHNQMCCETPPTVTVYVKS GSNRSHQPKKPITLKRPICK DNWQAFEKNTHNNNKSKRPK GPCLVIQRQDMTAFFKLFDD DLIQDFLWMDCCCKIADKYL LAMTFVYFKRAKFTISEHTR INFFIALYLANTVEEDEEET KYEIFPWALGKNWRKLFPNF LKLRDQLWDRIDYRAIVSRR CCEEVMAIAPTHYIWQRERS VHHSGAVRNYNRDEVQLPRG PSATPVDCSLCGKKRRYVR |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human SPDYA (NP_877433.2). |
| Tissue Specificity | Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. |
| Function | Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Mediates cell survival during the DNA damage process through activation of CDK2. |
| Protein Name | Speedy Protein ARapid Inducer Of G2/M Progression In Oocytes ARingo AHspy/Ringo ASpeedy-1Spy1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Speedy Protein A antibodyAnti-Rapid Inducer Of G2/M Progression In Oocytes A antibodyAnti-Ringo A antibodyAnti-Hspy/Ringo A antibodyAnti-Speedy-1 antibodyAnti-Spy1 antibodyAnti-SPDYA antibodyAnti-SPDY1 antibodyAnti-SPY1 antibody |
Information sourced from Uniprot.org
