| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SP110 |
| Gene ID: | 3431 |
| Uniprot ID: | SP110_HUMAN |
| Immunogen Region: | 1-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SP110 (NP_004501.3). |
| Immunogen Sequence: | MFTMTRAMEEALFQHFMHQK LGIAYAIHKPFPFFEGLLDN SIITKRMYMESLEACRNLIP VSRVVHNILTQLERTFNLSL LVTLFSQINLREYPNLVTIY RSFKRVGASYERQSRDTPIL LEAPTGLAEGSSLHTPLALP PPQPPQPSCSPCAPRVSEPG TSSQQSDEILSESPSPSDPV LPLPALIQEGRSTSVTNDKL TSKMNAEEDSEEMPSLLTST VQVASDNLIPQIRDKEDPQ |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Phosphorylated (isoform 2). |
| Function | Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). |
| Protein Name | Sp110 Nuclear Body Protein Interferon-Induced Protein 41/75 Speckled 110 Kda Transcriptional Coactivator Sp110 |
| Cellular Localisation | Nucleus Found In The Nuclear Body |
| Alternative Antibody Names | Anti-Sp110 Nuclear Body Protein antibody Anti-Interferon-Induced Protein 41/75 antibody Anti-Speckled 110 Kda antibody Anti-Transcriptional Coactivator Sp110 antibody Anti-SP110 antibody |
Information sourced from Uniprot.org