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Anti-SOX2 antibody (1-68 aa) [R74-1A-2] (STJA0016073)

Immunofluorescence analysis of SOX2 in NCCIT cells using SOX2 antibody (green) , and DAPI (blue).
Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma using SOX2 antibody. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.
Western blot analysis of SOX2 in (1) NCCIT lysates; (2) F9 lysates using SOX2 antibody.

Anti-SOX2 antibody (1-68 aa) [R74-1A-2] (STJA0016073)

SKU:

STJA0016073-100

$357.08

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General Information
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Host:	Rabbit
Applications:	WB/IHC-P/ICC/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-SOX2 (1-68 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	R74-1A-2
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification:	Affinity Chromatography
Concentration:	-
Dilution Range:	WB 1:500-1:1000 IHC 1:100-1:200 IF 1:50-1:200
Storage Instruction:	Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.

Gene Symbol:	SOX2
Gene ID:	6657
Uniprot ID:	SOX2_HUMAN
Immunogen Region:	1-68 aa
Immunogen:	A synthesized peptide derived from human SOX2

Post Translational Modifications	Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation. Ubiquitinated by WWP2, leading to proteasomal degradation.
Function	Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
Protein Name	Transcription Factor Sox-2
Database Links	Reactome: R-HSA-2892245 Reactome: R-HSA-2892247 Reactome: R-HSA-3769402 Reactome: R-HSA-452723 Reactome: R-HSA-6785807 Reactome: R-HSA-8986944 Reactome: R-HSA-9754189 Reactome: R-HSA-9823739 Reactome: R-HSA-9832991 Reactome: R-HSA-9834899 Reactome: R-HSA-9856649
Cellular Localisation	Nucleus Speckle Cytoplasm Nucleus Acetylation Contributes To Its Nuclear Localization And Deacetylation By Hdac3 Induces A Cytoplasmic Delocalization Colocalizes In The Nucleus With Znf208 Isoform Krab-O And Tyrosine Hydroxylase (Th) Colocalizes With Sox6 In Speckles Colocalizes With Caml In The Nucleus Nuclear Import Is Facilitated By Xpo4 A Protein That Usually Acts As A Nuclear Export Signal Receptor
Alternative Antibody Names	Anti-Transcription Factor Sox-2 antibody Anti-SOX2 antibody

Information sourced from Uniprot.org

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