| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SORBS1/ponsin (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave an approx 65kDa band in Human Adipose lysates after 0.3µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SORBS1 |
| Gene ID: | 10580 |
| Uniprot ID: | SRBS1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1 |
| Specificity: | This antibody is expected to recognise all reported isoforms (NP_006425.2 and NP_056200.1 and NP_001030126.1 and NP_001030127.1 and NP_001030128.1 and NP_079267.1 and NP_001030129.1) |
| Immunogen Sequence: | SERNDWEPPDKKVD |
| Post Translational Modifications | O-glycosylated. |
| Function | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. |
| Protein Name | Sorbin And Sh3 Domain-Containing Protein 1PonsinSh3 Domain Protein 5Sh3p12C-Cbl-Associated ProteinCap |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembraneCytoplasmCytoskeletonFocal AdhesionNucleusNucleus MatrixColocalizes With The Ten-1 Icd Form Of Tenm1 In The NucleusColocalizes With Actin Stress FibersAlso Detected At The Plasma Membrane And In Neuronal Intranuclear InclusionsColocalized With Pxn At Focal Adhesions During Myogenic Differentiation |
| Alternative Antibody Names | Anti-Sorbin And Sh3 Domain-Containing Protein 1 antibodyAnti-Ponsin antibodyAnti-Sh3 Domain Protein 5 antibodyAnti-Sh3p12 antibodyAnti-C-Cbl-Associated Protein antibodyAnti-Cap antibodyAnti-SORBS1 antibodyAnti-KIAA0894 antibodyAnti-KIAA1296 antibodyAnti-SH3D5 antibody |
Information sourced from Uniprot.org