Anti-SORBS1/ponsin antibody (Internal) (STJ71125)

SKU:
STJ71125-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SORBS1/ponsin (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-3.75µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SORBS1
Gene ID: 10580
Uniprot ID: SRBS1_HUMAN
Immunogen Region: Internal
Accession Number: NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1
Specificity: This antibody is expected to recognise all reported isoforms (NP_006425.2 and NP_056200.1 and NP_001030126.1 and NP_001030127.1 and NP_001030128.1 and NP_079267.1 and NP_001030129.1)
Immunogen Sequence: SERNDWEPPDKKVD
Post Translational Modifications O-glycosylated.
Function Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Protein Name Sorbin And Sh3 Domain-Containing Protein 1
Ponsin
Sh3 Domain Protein 5
Sh3p12
C-Cbl-Associated Protein
Cap
Database Links Reactome: R-HSA-445355
Cellular Localisation Cell Junction
Adherens Junction
Cell Membrane
Cytoplasm
Cytoskeleton
Focal Adhesion
Nucleus
Nucleus Matrix
Colocalizes With The Ten-1 Icd Form Of Tenm1 In The Nucleus
Colocalizes With Actin Stress Fibers
Also Detected At The Plasma Membrane And In Neuronal Intranuclear Inclusions
Colocalized With Pxn At Focal Adhesions During Myogenic Differentiation
Alternative Antibody Names Anti-Sorbin And Sh3 Domain-Containing Protein 1 antibody
Anti-Ponsin antibody
Anti-Sh3 Domain Protein 5 antibody
Anti-Sh3p12 antibody
Anti-C-Cbl-Associated Protein antibody
Anti-Cap antibody
Anti-SORBS1 antibody
Anti-KIAA0894 antibody
Anti-KIAA1296 antibody
Anti-SH3D5 antibody

Information sourced from Uniprot.org

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