| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-SORBS1/ponsin (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-5µg/mlELISA-antibody detection limit dilution 1:2000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SORBS1 |
| Gene ID: |
10580 |
| Uniprot ID: |
SRBS1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1 |
| Specificity: |
This antibody is expected to recognise all 7 reported isoforms (NP_006425.2, NP_056200.1, NP_001030126.1, NP_001030127.1, NP_001030128.1, NP_079267.1 and NP_001030129.1). |
| Immunogen Sequence: |
SPKSEDDDSDLYSP |
| Post Translational Modifications | O-glycosylated. |
| Function | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. |
| Protein Name | Sorbin And Sh3 Domain-Containing Protein 1PonsinSh3 Domain Protein 5Sh3p12C-Cbl-Associated ProteinCap |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembraneCytoplasmCytoskeletonFocal AdhesionNucleusNucleus MatrixColocalizes With The Ten-1 Icd Form Of Tenm1 In The NucleusColocalizes With Actin Stress FibersAlso Detected At The Plasma Membrane And In Neuronal Intranuclear InclusionsColocalized With Pxn At Focal Adhesions During Myogenic Differentiation |
| Alternative Antibody Names | Anti-Sorbin And Sh3 Domain-Containing Protein 1 antibodyAnti-Ponsin antibodyAnti-Sh3 Domain Protein 5 antibodyAnti-Sh3p12 antibodyAnti-C-Cbl-Associated Protein antibodyAnti-Cap antibodyAnti-SORBS1 antibodyAnti-KIAA0894 antibodyAnti-KIAA1296 antibodyAnti-SH3D5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
