| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SON |
| Gene ID: | 6651 |
| Uniprot ID: | SON_HUMAN |
| Immunogen Region: | 850-950 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 850-950 of human SON (NP_001278340.1). |
| Immunogen Sequence: | TMDSQMLATSSMDSQMLASG TMDSQMLASGTMDAQMLASG TMDAQMLASSTQDSAMLGSK SPDPYRLAQDPYRLAQDPYR LGHDPYRLGHDAYRLGQDPY R |
| Tissue Specificity | Widely expressed, with the higher expression seen in leukocyte and heart. |
| Function | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA.binds to the consensus DNA sequence: 5'-GAGTANCGAGCC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1. |
| Protein Name | Protein Son Bax Antagonist Selected In Saccharomyces 1 Bass1 Negative Regulatory Element-Binding Protein Nre-Binding Protein Protein Dbp-5 Son3 |
| Cellular Localisation | Nucleus Speckle Colocalizes With The Pre-Mrna Splicing Factor Srsf2 |
| Alternative Antibody Names | Anti-Protein Son antibody Anti-Bax Antagonist Selected In Saccharomyces 1 antibody Anti-Bass1 antibody Anti-Negative Regulatory Element-Binding Protein antibody Anti-Nre-Binding Protein antibody Anti-Protein Dbp-5 antibody Anti-Son3 antibody Anti-SON antibody Anti-C21orf50 antibody Anti-DBP5 antibody Anti-KIAA1019 antibody Anti-NREBP antibody Anti-HSPC310 antibody Anti-HSPC312 antibody |
Information sourced from Uniprot.org