Anti-SOGA1 antibody (650-750) (STJ119024)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SOGA1 (650-750) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTCL2 |
| Gene ID | 140710 |
| Uniprot ID | MTCL2_HUMAN |
| Immunogen Region | 650-750 |
| Immunogen Sequence | AEVLPGLREQAALVSKAIDV LVADANGFTAGLRLCLDNEC ADFRLHEAPDNSEGPRDTKL IHAILVRLSVLQQELNAFTR KADAVLGCSVKEQQESFSSL P |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 650-750 of human SOGA1 (NP_542194.2). |
Additional Info
| Post Translational Modifications | Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form. Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma. Phosphorylated during mitosis in a CDK1-dependent manner. |
| Function | Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain. Required for faithful chromosome segregation during mitosis. Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. |
| Protein Name | Microtubule Cross-Linking Factor 2Soga Family Member 1Suppressor Of Glucose By AutophagySuppressor Of Glucose - Autophagy-Associated Protein 1 Cleaved Into - N-Terminal Form - C-Terminal 80 Kda Form80-Kda Soga Fragment |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonGolgi Apparatus MembraneMidbodyAssociates With Microtubules During Late Mitosis And InterphaseC-Terminal 80 Kda Form: SecretedSecreted In Primary Hepatocyte-Conditioned Media |
| Alternative Antibody Names | Anti-Microtubule Cross-Linking Factor 2 antibodyAnti-Soga Family Member 1 antibodyAnti-Suppressor Of Glucose By Autophagy antibodyAnti-Suppressor Of Glucose - Autophagy-Associated Protein 1 Cleaved Into - N-Terminal Form - C-Terminal 80 Kda Form antibodyAnti-80-Kda Soga Fragment antibodyAnti-MTCL2 antibodyAnti-C20orf117 antibodyAnti-KIAA0889 antibodyAnti-SOGA antibodyAnti-SOGA1 antibody |
Information sourced from Uniprot.org