| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOCS3 |
| Gene ID: | 9021 |
| Uniprot ID: | SOCS3_HUMAN |
| Immunogen Region: | 1-225 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-225 of human SOCS3 (NP_003946.3). |
| Immunogen Sequence: | MVTHSKFPAAGMSRPLDTSL RLKTFSSKSEYQLVVNAVRK LQESGFYWSAVTGGEANLLL SAEPAGTFLIRDSSDQRHFF TLSVKTQSGTKNLRIQCEGG SFSLQSDPRSTQPVPRFDCV LKLVHHYMPPPGAPSFPSPP TEPSSEVPEQPSAQPLPGSP PRRAYYIYSGGEKIPLVLSR PLSSNVATLQHLCRKTVNGH LDSYEKVTQLPGPIREFLDQ YDAPL |
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| Post Translational Modifications | Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 3Socs-3Cytokine-Inducible Sh2 Protein 3Cis-3Stat-Induced Stat Inhibitor 3Ssi-3 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-2586552Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-8849474Reactome: R-HSA-8939242Reactome: R-HSA-8951664Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9705462Reactome: R-HSA-982772Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 3 antibodyAnti-Socs-3 antibodyAnti-Cytokine-Inducible Sh2 Protein 3 antibodyAnti-Cis-3 antibodyAnti-Stat-Induced Stat Inhibitor 3 antibodyAnti-Ssi-3 antibodyAnti-SOCS3 antibodyAnti-CIS3 antibodyAnti-SSI3 antibody |
Information sourced from Uniprot.org
