Anti-SOCS1 antibody (1-211) (STJ110065)

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STJ110065
£112.50 - £524.50
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SOCS1
Gene ID: 8651
Uniprot ID: SOCS1_HUMAN
Immunogen Region: 1-211
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SOCS1 (NP_003736.1).
Immunogen Sequence: MVAHNQVAADNAVSTAAEPR RRPEPSSSSSSSPAAPARPR PCPAVPAPAPGDTHFRTFRS HADYRRITRASALLDACGFY WGPLSVHGAHERLRAEPVGT
Tissue Specificity Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Function Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 1
Socs-1
Jak-Binding Protein
Jab
Stat-Induced Stat Inhibitor 1
Ssi-1
Tec-Interacting Protein 3
Tip-3
Database Links Reactome: R-HSA-1266695
Reactome: R-HSA-1433559
Reactome: R-HSA-166058
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-909733
Reactome: R-HSA-912694
Reactome: R-HSA-9674555
Reactome: R-HSA-9705462
Reactome: R-HSA-982772
Reactome: R-HSA-983168
Cellular Localisation Nucleus
Cytoplasmic Vesicle
Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3
Alternative Antibody Names Anti-Suppressor Of Cytokine Signaling 1 antibody
Anti-Socs-1 antibody
Anti-Jak-Binding Protein antibody
Anti-Jab antibody
Anti-Stat-Induced Stat Inhibitor 1 antibody
Anti-Ssi-1 antibody
Anti-Tec-Interacting Protein 3 antibody
Anti-Tip-3 antibody
Anti-SOCS1 antibody
Anti-SSI1 antibody
Anti-TIP3 antibody

Information sourced from Uniprot.org