| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SOAT2 |
| Gene ID: |
8435 |
| Uniprot ID: |
SOAT2_HUMAN |
| Immunogen Region: |
1-120 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SOAT2 (NP_003569.1). |
| Immunogen Sequence: |
MEPGGARLRLQRTEGLGGER ERQPCGDGNTETHRAPDLVQ WTRHMEAVKAQLLEQAQGQL RELLDRAMREAIQSYPSQDK PLPPPPPGSLSRTQEPSLGK QKVFIIRKSLLDELMEVQHF |
| Tissue Specificity | Expression seems confined in hepatocytes and enterocytes. |
| Post Translational Modifications | Polyubiquitinated by AMFR/gp78 at Cys-277, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-277 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. Oxidized at Cys-277: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-277, preventing ubiquitination at the same site, and resulting in protein stabilization. |
| Function | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Isoform 2: Has lower enzymatic activity compared to isoform 1. Isoform 3: Has lower enzymatic activity compared to isoform 1. |
| Protein Name | Sterol O-Acyltransferase 2Acyl-Coenzyme A -Cholesterol Acyltransferase 2Acat-2Cholesterol Acyltransferase 2 |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sterol O-Acyltransferase 2 antibodyAnti-Acyl-Coenzyme A -Cholesterol Acyltransferase 2 antibodyAnti-Acat-2 antibodyAnti-Cholesterol Acyltransferase 2 antibodyAnti-SOAT2 antibodyAnti-ACACT2 antibodyAnti-ACAT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
