Anti-SNRNP70 antibody (150-250) (STJ27859)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SNRNP70 (150-250) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNRNP70 |
| Gene ID | 6625 |
| Uniprot ID | RU17_HUMAN |
| Immunogen Region | 150-250 |
| Immunogen Sequence | EYEHERDMHSAYKHADGKKI DGRRVLVDVERGRTVKGWRP RRLGGGLGGTRRGGADVNIR HSGRDDTSRYDERPGPSPLP HRDRDRDRERERRERSRERD K |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SNRNP70 (NP_003080.2). |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. Extensively phosphorylated on serine residues in the C-terminal region. |
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. |
| Protein Name | U1 Small Nuclear Ribonucleoprotein 70 KdaU1 Snrnp 70 KdaU1-70kSnrnp70 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmColocalizes With Scnm1 And Luc7l2 In Nuclear Speckles |
| Alternative Antibody Names | Anti-U1 Small Nuclear Ribonucleoprotein 70 Kda antibodyAnti-U1 Snrnp 70 Kda antibodyAnti-U1-70k antibodyAnti-Snrnp70 antibodyAnti-SNRNP70 antibodyAnti-RNPU1Z antibodyAnti-RPU1 antibodyAnti-SNRP70 antibodyAnti-U1AP1 antibody |
Information sourced from Uniprot.org