| Post Translational Modifications | The N-terminus is blocked. Extensively phosphorylated on serine residues in the C-terminal region. |
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. |
| Protein Name | U1 Small Nuclear Ribonucleoprotein 70 KdaU1 Snrnp 70 KdaU1-70kSnrnp70 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmColocalizes With Scnm1 And Luc7l2 In Nuclear Speckles |
| Alternative Antibody Names | Anti-U1 Small Nuclear Ribonucleoprotein 70 Kda antibodyAnti-U1 Snrnp 70 Kda antibodyAnti-U1-70k antibodyAnti-Snrnp70 antibodyAnti-SNRNP70 antibodyAnti-RNPU1Z antibodyAnti-RPU1 antibodyAnti-SNRP70 antibodyAnti-U1AP1 antibody |
Information sourced from Uniprot.org
