| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNIP1 |
| Gene ID: | 79753 |
| Uniprot ID: | SNIP1_HUMAN |
| Immunogen Region: | 200-300 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SNIP1 (NP_078976.2). |
| Immunogen Sequence: | SESQELVPRPGGNNKEKEVP AKEKPSFELSGALLEDTNTF RGVVIKYSEPPEARIPKKRW RLYPFKNDEVLPVMYIHRQS AYLLGRHRRIADIPIDHPSC S |
| Tissue Specificity | Ubiquitous, with highest expression in heart and skeletal muscle. |
| Post Translational Modifications | Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex. |
| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. |
| Protein Name | Smad Nuclear-Interacting Protein 1Fha Domain-Containing Protein Snip1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Smad Nuclear-Interacting Protein 1 antibodyAnti-Fha Domain-Containing Protein Snip1 antibodyAnti-SNIP1 antibody |
Information sourced from Uniprot.org