| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Staphylococcal nuclease domain-containing protein 1 (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SND1 |
| Gene ID: |
27044 |
| Uniprot ID: |
SND1_HUMAN |
| Immunogen Region: |
Internal |
| Specificity: |
TudorSN Polyclonal Antibody detects endogenous levels of TudorSN protein. |
| Immunogen: |
Synthesized peptide derived from the Internal region of human TudorSN. |
| Post Translational Modifications | Phosphorylated by PIM1 in vitro. |
| Function | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). |
| Protein Name | Staphylococcal Nuclease Domain-Containing Protein 1100 Kda CoactivatorEbna2 Coactivator P100Tudor Domain-Containing Protein 11P100 Co-Activator |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | CytoplasmNucleusMelanosomeIn Il-4 Stimulated Cells Colocalizes With Stat6 In The NucleusIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Staphylococcal Nuclease Domain-Containing Protein 1 antibodyAnti-100 Kda Coactivator antibodyAnti-Ebna2 Coactivator P100 antibodyAnti-Tudor Domain-Containing Protein 11 antibodyAnti-P100 Co-Activator antibodyAnti-SND1 antibodyAnti-TDRD11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and SND1 knockout (KO) HeLa cells, using [KO Validated] SND1 Rabbit polyclonal antibody (STJ115376) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/94407/375997/STJ115376_1__50846.1713142920.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SND1 knockout (KO) HeLa cells, using [KO Validated] SND1 Rabbit polyclonal antibody (STJ115376) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
