Anti-SNAPIN antibody (1-136) (STJ112332)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SNAPIN (1-136) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNAPIN |
| Gene ID | 23557 |
| Uniprot ID | SNAPN_HUMAN |
| Immunogen Region | 1-136 |
| Immunogen Sequence | MAGAGSAAVSGAGTPVAGPT GRDLFAEGLLEFLRPAVQQL DSHVHAVRESQVELREQIDN LATELCRINEDQKVALDLDP YVKKLLNARRRVVLVNNILQ NAQERLRRLNHSVAKETARR RAMLDSGIYPPGSPGK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SNAPIN (NP_036569.1). |
Additional Info
| Tissue Specificity | Expressed in male germ cells of adult testis (at protein level). |
| Post Translational Modifications | Phosphorylated by CSNK1D/CK1. Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability. |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. |
| Protein Name | Snare-Associated Protein SnapinBiogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7Bloc-1 Subunit 7Synaptosomal-Associated Protein 25-Binding ProteinSnap-Associated Protein |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolPerinuclear RegionGolgi Apparatus MembraneLysosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneColocalizes With Nanos1 And Pum2 In The Perinuclear Region Of Germ Cells |
| Alternative Antibody Names | Anti-Snare-Associated Protein Snapin antibodyAnti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7 antibodyAnti-Bloc-1 Subunit 7 antibodyAnti-Synaptosomal-Associated Protein 25-Binding Protein antibodyAnti-Snap-Associated Protein antibodyAnti-SNAPIN antibodyAnti-BLOC1S7 antibodyAnti-SNAP25BP antibodyAnti-SNAPAP antibody |
Information sourced from Uniprot.org