| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNAPIN |
| Gene ID: | 23557 |
| Uniprot ID: | SNAPN_HUMAN |
| Immunogen Region: | 1-136 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SNAPIN (NP_036569.1). |
| Immunogen Sequence: | MAGAGSAAVSGAGTPVAGPT GRDLFAEGLLEFLRPAVQQL DSHVHAVRESQVELREQIDN LATELCRINEDQKVALDLDP YVKKLLNARRRVVLVNNILQ NAQERLRRLNHSVAKETARR RAMLDSGIYPPGSPGK |
| Tissue Specificity | Expressed in male germ cells of adult testis (at protein level). |
| Post Translational Modifications | Phosphorylated by CSNK1D/CK1. Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability. |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. |
| Protein Name | Snare-Associated Protein Snapin Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7 Bloc-1 Subunit 7 Synaptosomal-Associated Protein 25-Binding Protein Snap-Associated Protein |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasm Cytosol Perinuclear Region Golgi Apparatus Membrane Lysosome Membrane Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Colocalizes With Nanos1 And Pum2 In The Perinuclear Region Of Germ Cells |
| Alternative Antibody Names | Anti-Snare-Associated Protein Snapin antibody Anti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7 antibody Anti-Bloc-1 Subunit 7 antibody Anti-Synaptosomal-Associated Protein 25-Binding Protein antibody Anti-Snap-Associated Protein antibody Anti-SNAPIN antibody Anti-BLOC1S7 antibody Anti-SNAP25BP antibody Anti-SNAPAP antibody |
Information sourced from Uniprot.org