| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 IHC-P:1:20-1:200 IF/ICC:1:20-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SMYD1 |
| Gene ID: | 150572 |
| Uniprot ID: | SMYD1_HUMAN |
| Immunogen Region: | 1-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human SMYD1 (NP_938015.1). |
| Immunogen Sequence: | MTIGRMENVEVFTAEGKGRG LKATKEFWAADIIFAERAYS AVVFDSLVNFVCHTCFKRQE KLHRCGQCKFAHYCDRTCQK DAWLNHKNECSAIKRYGKVP NENIRLAARIMWRVEREGTG LTEGCLVSVDDLQNHVEHFG EEEQKDLRVDVDTFLQYWPP QSQQFSMQYISHIFGVINCN GFTLSDQRGLQAVGVGIFPN LGLVNHDCWPNCTVIFNNGN HEAVKSMFHTQMRIELRAL |
| Tissue Specificity | Expression seems mostly restricted to heart and skeletal muscle. |
| Function | Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. |
| Protein Name | Histone-Lysine N-Methyltransferase Smyd1 Set And Mynd Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-9733709 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Smyd1 antibody Anti-Set And Mynd Domain-Containing Protein 1 antibody Anti-SMYD1 antibody |
Information sourced from Uniprot.org