| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SMOX |
| Gene ID: | 54498 |
| Uniprot ID: | SMOX_HUMAN |
| Immunogen Region: | 300-544 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-544 of human SMOX (NP_787033.1). |
| Immunogen Sequence: | PRGGRWDEDEQWSVVVECED CELIPADHVIVTVSLGVLKR QYTSFFRPGLPTEKVAAIHR LGIGTTDKIFLEFEEPFWGP ECNSLQFVWEDEAESHTLTY PPELWYRKICGFDVLYPPER YGHVLSGWICGEEALVMEKC DDEAVAEICTEMLRQFTGNP NIPKPRRILRSAWGSNPYFR GSYSYTQVGSSGADVEKLAK PLPYTESSKTAPMQVLFSGE ATHRKYYSTTHGALLSGQR |
| Tissue Specificity | Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. |
| Function | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
| Protein Name | Spermine OxidasePolyamine Oxidase 1Pao-1Paoh1 |
| Database Links | Reactome: R-HSA-141334 Q9NWM0-3Reactome: R-HSA-351200 Q9NWM0-3 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 4: CytoplasmIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Spermine Oxidase antibodyAnti-Polyamine Oxidase 1 antibodyAnti-Pao-1 antibodyAnti-Paoh1 antibodyAnti-SMOX antibodyAnti-C20orf16 antibodyAnti-SMO antibodyAnti-UNQ3039 antibodyAnti-PRO9854 antibody |
Information sourced from Uniprot.org