| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLK |
| Gene ID: | 9748 |
| Uniprot ID: | SLK_HUMAN |
| Immunogen Region: | 1-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human SLK (NP_055535.2). |
| Immunogen Sequence: | MSFFNFRKIFKLGSEKKKKQ YEHVKRDLNPEDFWEIIGEL GDGAFGKVYKAQNKETSVLA AAKVIDTKSEEELEDYMVEI DILASCDHPNIVKLLDAFYY ENNLWILIEFCAGGAVDAVM LELERPLTESQIQVVCKQTL DALNYLHDNKIIHRDLKAGN ILFTLDGDIKLADFGVSAKN TRTIQRRDSFIGTPYWMAPE VVMCETSKDRPYDYKADVWS LGITLIEMAE |
| Tissue Specificity | Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. |
| Post Translational Modifications | Proteolytically cleaved by caspase-3. Autophosphorylated. |
| Function | Mediates apoptosis and actin stress fiber dissolution. |
| Protein Name | Ste20-Like Serine/Threonine-Protein KinaseSte20-Like KinaseHslkCtcl Tumor Antigen Se20-9Ste20-Related Serine/Threonine-Protein KinaseSte20-Related KinaseSerine/Threonine-Protein Kinase 2 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ste20-Like Serine/Threonine-Protein Kinase antibodyAnti-Ste20-Like Kinase antibodyAnti-Hslk antibodyAnti-Ctcl Tumor Antigen Se20-9 antibodyAnti-Ste20-Related Serine/Threonine-Protein Kinase antibodyAnti-Ste20-Related Kinase antibodyAnti-Serine/Threonine-Protein Kinase 2 antibodyAnti-SLK antibodyAnti-KIAA0204 antibodyAnti-STK2 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and FANCD2 knockout (KO) HeLa cells, using [KO Validated] FANCD2 Rabbit polyclonal antibody (STJ11100028) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89100/357559/STJ11100028_1__98700.1713121684.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and FANCD2 knockout (KO) HeLa cells, using [KO Validated] FANCD2 Rabbit polyclonal antibody (STJ11100028) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")
