| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Sodium/hydrogen exchanger 9/H+ exchanger 9 (171-220) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC9A9 |
| Gene ID: | 285195 |
| Uniprot ID: | SL9A9_HUMAN |
| Immunogen Region: | 171-220 |
| Specificity: | NHE-9 Polyclonal Antibody detects endogenous levels of NHE-9 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human SLC9A9. AA range:171-220 |
| Tissue Specificity | Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord. |
| Function | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain. Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH. |
| Protein Name | Sodium/Hydrogen Exchanger 9 Na(+/H(+ Exchanger 9 Nhe-9 Solute Carrier Family 9 Member 9 |
| Database Links | Reactome: R-HSA-425986 Reactome: R-HSA-5619052 |
| Cellular Localisation | Late Endosome Membrane Multi-Pass Membrane Protein Early Endosome Membrane Recycling Endosome Membrane Cell Membrane Cytoplasmic Vesicle Phagosome Membrane Localized To The Plasma Membrane In Inner Ear Hair Cell Bundle |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 9 antibody Anti-Na(+/H(+ Exchanger 9 antibody Anti-Nhe-9 antibody Anti-Solute Carrier Family 9 Member 9 antibody Anti-SLC9A9 antibody Anti-NHE9 antibody Anti-Nbla00118 antibody |
Information sourced from Uniprot.org